The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies.

Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic. Serologic HLA matching has been the standard for solid organ allocation algorithms in current use. Antibodies do not recognize whole HLA molecules but rather polymorphic residues on the surface, called epitopes, which may be shared by multiple serologic HLA antigens. Data are accumulating that epitope analysis may be a better way to determine organ compatibility as well as the potential immunogenicity of given HLA mismatches. Determination of the pathogenicity of alloantibodies is evolving. Potential features include antibody strength (as assessed by antibody titer or, more commonly and inappropriately, mean fluorescence intensity) and ability to fix complement (in vitro by C1q or C3d assay or by IgG subclass analysis). Technical issues with the use of solid phase assays are also of prime importance, such as denaturation of HLA antigens and manufacturing and laboratory variability. Questions and controversies remain, and here we review new relevant data

Nonlinear zero-sum differential game analysis by singular perturbation methods

A class of nonlinear, zero-sum differential games, exhibiting time-scale separation properties, can be analyzed by singular-perturbation techniques. The merits of such an analysis, leading to an approximate game solution, as well as the 'well-posedness' of the formulation, are discussed. This approach is shown to be attractive for investigating pursuit-evasion problems; the original multidimensional differential game is decomposed to a 'simple pursuit' (free-stream) game and two independent (boundary-layer) optimal-control problems. Using multiple time-scale boundary-layer models results in a pair of uniformly valid zero-order composite feedback strategies. The dependence of suboptimal strategies on relative geometry and own-state measurements is demonstrated by a three dimensional, constant-speed example. For game analysis with realistic vehicle dynamics, the technique of forced singular perturbations and a variable modeling approach is proposed. Accuracy of the analysis is evaluated by comparison with the numerical solution of a time-optimal, variable-speed 'game of two cars' in the horizontal plane

Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles.

Methods for the construction of thiazolo-, thiazino-, and thiazepino-2H-indazoles from o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1°-aminothioalkanes are reported. The process consists of formation of the requisite N-(2-nitrobenzyl)(tritylthio)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediate treatment with aq. KOH in methanol under Davis-Beirut reaction conditions to deliver the target thiazolo-, thiazino-, or thiazepino-2H-indazole in good overall yield. Subsequent S-oxidation gives the corresponding sulfone

Innovation in the Wireless Ecosystem: A Customer-Centric Framework

The Federal Communications Commission’s Notice of Inquiry in GN 09-157 Fostering Innovation and Investment in the Wireless Communications Market is a significant event at an opportune moment. Wireless communications has already radically changed the way not only Americans but people the world over communicate with each other and access and share information, and there appears no end in sight to this fundamental shift in communication markets. Although the wireless communications phenomenon is global, the US has played and will continue to play a major role in the shaping of this market. At the start of a new US Administration and important changes in the FCC, it is most appropriate that this proceeding be launched.

Lyapunov 1-forms for flows

In this paper we find conditions which guarantee that a given flow $\Phi$ on a compact metric space $X$ admits a Lyapunov one-form $\omega$ lying in a prescribed \v{C}ech cohomology class $\xi\in \check H^1(X;\R)$. These conditions are formulated in terms of the restriction of $\xi$ to the chain recurrent set of $\Phi$. The result of the paper may be viewed as a generalization of a well-known theorem of C. Conley about the existence of Lyapunov functions.Comment: 27 pages, 3 figures. This revised version incorporates a few minor improvement

L^2 torsion without the determinant class condition and extended L^2 cohomology

We associate determinant lines to objects of the extended abelian category built out of a von Neumann category with a trace. Using this we suggest constructions of the combinatorial and the analytic L^2 torsions which, unlike the work of the previous authors, requires no additional assumptions; in particular we do not impose the determinant class condition. The resulting torsions are elements of the determinant line of the extended L^2 cohomology. Under the determinant class assumption the L^2 torsions of this paper specialize to the invariants studied in our previous work. Applying a recent theorem of D. Burghelea, L. Friedlander and T. Kappeler we obtain a Cheeger - Muller type theorem stating the equality between the combinatorial and the analytic L^2 torsions.Comment: 39 page

Spectrum Management: Property Rights, Markets, and The Commons

Gerald Faulhaber and David Farberconsider alternatives to the current licensing regime for spectrum, which appears to lead to substantial inefficiencies in spectrum allocation.Specifically, they examine two property rights regimes and a commons regime.Theynote that economists have favored a market-based regime while engineers have favored a commons-based regime to promote new technologies. Mr. Faulhaber and Mr. Farbershow that thereis aproperty rights market-based regime that unleashes the power of the market andthe power of the new technologies to efficiently allocate spectrum, and that is likely to meet our needs for the near-term future. This regime resolves the presumed dichotomy between the market-based and the commons-based views, so that both objectives can be realized.The authorsalso outline a transition processfor achieving the desired regime outcome that is a "win-win" for all stakeholders, and that could be politically feasible. The change to a property rights regime is likely to lower the cost of spectrum substantially, in many cases to zero.Mr. Faulhaber and Mr. Farberassert that a commons model and a market model can co-exist, at least until spectrum becomes truly scarce.

Measuring segregation using patterns of daily travel behavior : a social interaction based model of exposure

Recent advances in transportation geography demonstrate the ability to compute a metropolitan scale metric of social interaction opportunities based on the time-geographic concept of joint accessibility. The method we put forward in this article decomposes the social interaction potential (SIP) metric into interactions within and between social groups, such as people of different race, income level, and occupation. This provides a novel metric of exposure, one of the fundamental spatial dimensions of segregation. In particular, the SIP metric is disaggregated into measures of inter-group and intra-group exposure. While activity spaces have been used to measure exposure in the geographic literature, these approaches do not adequately represent the dynamic nature of the target populations. We make the next step by representing both the source and target population groups by space-time prisms, thus more accurately representing spatial and temporal dynamics and constraints. Additionally, decomposition of the SIP metric means that each of the group-wise components of the SIP metric can be represented at zones of residence, workplace, and specific origin-destination pairs. Consequently, the spatial variation in segregation can be explored and hotspots of segregation and integration potential can be identified. The proposed approach is demonstrated for synthetic cities with different population distributions and daily commute flow characteristics, as well as for a case study of the Detroit-Warren-Livonia MSA